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tabacum (2 n =4 x =48) evolved through the interspecific hybridization of the ancestors of Nicotiana sylvestris (2 n =24, maternal donor) and Nicotiana tomentosiformis (2 n =24, paternal donor) about 200,000 years ago 13
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However, disease recurrence is almost the rule after a curative resection and, for this reason, preventive algorithms have been repeatedly proposed[34,35]
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